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Insulin Sensitizers Good or Bad
By ]Steve Freed
Cardiovascular Risk With an Insulin Sensitizers - Let's put it in perspective!
With the current New England Journal Article on Avandia and it's increased risks for cardiovascular problems, I believe we have missed the whole point of the article.
So, we have the insulin sensitizers, Avandia, Actos and Rezulin (which was removed from the marketplace for liver toxicity). Risk factors for these include heart attacks, cardiovascular death, fluid retention, bone fractures, weight increase, negative effect on lipids and possible unknown effects on genes. The New England Journal of Medicine published an article entitled, "Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes." The conclusions of this analysis of previous studies of rosiglitazone (brand name, Avandia) suggest that this oral agent used to treat type 2 diabetes may be associated with increased risk of heart attack by 43 percent and and death from cardiovascular causes by 64 percent. In an editorial review of the Avandia meta-analysis, also published in the New England Journal of Medicine, Drs. Psaty and Furberg indicated that the approval process for Avandia may have been insufficiently rigorous because rosiglitazone has so many effects on genes, many of which are unknown.
Moreover, its approval was based upon studies that may have been too short to be really useful in identifying long-term adverse heart effects. Previously, meta-analysis was instrumental in preventing Pargluva (muraglitazar), a drug similar to Avandia, from being approved, again because of heart problems. In 2000, another glitazone, Rezulin (troglitazone), was removed from the market due to liver toxicity. Earlier this year, the Cochrane Library published a meta-analysis of Actos (pioglitazone), a thiazolidinedione similar to Avandia, which implicated it in edema and heart failure. In the meantime, patients using any of the insulin sensitizers should talk to their health care provider to determine the most appropriate course of action. Patients should not stop taking any prescribed medications without first discussing the issue with their health care provider. Now is the time to talk to your patients about the risks associated with diabetes. Using any drug increases your risk for complications. But, as the studies have shown, increasing your physical activity can provide the same benefits and even greater benefits in reducing your risk factors for the complications of diabetes and other diseases. Just like we all know that physical activity is an effective treatment for diabetes, yet we would rather just write another prescription for a drug treatment, rather then write a prescription for physical activity, which we all know works and is effective.
Lets first look at the costs of treating diabetes with Avandia. The cost to treat diabetes with Avandia can be $120 dollars a month, or 1500 a year or 15,000 for 10 years and increases your risk for DEATH!. A pedometer costs $20 dollars over 10 years, and when used effectively will reduce the risk for heart failure and DEATH! We can take the increased risk of death from cardiovascular of 64% and turn it around and decrease your risk for cardiovascular death by 64%, that is a change of 128%. As in the DPT trials, and even the Dream study, which used Avandia to reduce the risk of diabetes physical activity was shown to be as effective, if not more then the oral treatments used in the studies.
Lets look at a couple of the studies that, shows this controversy has but only one conclusion. In a Finish study with postmenopausal women over 10 years it was found that walking 1 mile or more a day reduced the risk for heart disease by 82%. In a study in Washington State they found that walking at least 1 hour per week, which is less then 9 minutes a day can reduce the risk for sudden cardiac death by 73%. In a study of 40,000 American females they found that walking at least 1 hour a week, (less then 10 minutes a day) reduced the risk for coronary artery disease by 51%. In a study of over 73,000 American women aged 50-79, walking for 2.5 hours a week reduced the risk for all cardiovascular events by 30%. In a study of 1500 men, walking at least 2.5 hours a week (14 minutes a day) lowered the risk of heat attack by 69%. So, why replace one drug with another that has other risk factors, when we can simply provide a 20 dollar pedometer and tell our patients to increase their physical activity? Now is a great time to have the discussion with your patients and let them know that there are other alternatives to taking drugs that are more effective with no risk factors. But, just telling them may not be good enough, make them responsible for reporting to you their physical activity by using a pedometer and setting goals for the number of steps they take each and every day. If they can report to you their blood sugars, then report their steps! Now imagine what would happen if we also had them responsible for the number of carbohydrates that they consume each day and maybe reduce them by just 100 grams, what could happen? And if all else fails, consider using the most safe and effective drug: INSULIN I
If you would like to share your comments, contact me at publisher@diabetesincontrol.com Steve Freed, Publisher Diabetes in Control.com Pharmacist and Diabetes Educator
Steve Freed, Pharmacist, Diabetes Educator, pedometrist and publisher of http://www.diabetesincontrol.com the leading on-line newsletter for diabetes information for medical professionals and patients with diabetes.
Article Source: http://EzineArticles.com/?expert=Steve_Freed http://EzineArticles.com/?Insulin-Sensitizers-Good-or-Bad&id=929953
By ]Steve Freed
Cardiovascular Risk With an Insulin Sensitizers - Let's put it in perspective!
With the current New England Journal Article on Avandia and it's increased risks for cardiovascular problems, I believe we have missed the whole point of the article.
So, we have the insulin sensitizers, Avandia, Actos and Rezulin (which was removed from the marketplace for liver toxicity). Risk factors for these include heart attacks, cardiovascular death, fluid retention, bone fractures, weight increase, negative effect on lipids and possible unknown effects on genes. The New England Journal of Medicine published an article entitled, "Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes." The conclusions of this analysis of previous studies of rosiglitazone (brand name, Avandia) suggest that this oral agent used to treat type 2 diabetes may be associated with increased risk of heart attack by 43 percent and and death from cardiovascular causes by 64 percent. In an editorial review of the Avandia meta-analysis, also published in the New England Journal of Medicine, Drs. Psaty and Furberg indicated that the approval process for Avandia may have been insufficiently rigorous because rosiglitazone has so many effects on genes, many of which are unknown.
Moreover, its approval was based upon studies that may have been too short to be really useful in identifying long-term adverse heart effects. Previously, meta-analysis was instrumental in preventing Pargluva (muraglitazar), a drug similar to Avandia, from being approved, again because of heart problems. In 2000, another glitazone, Rezulin (troglitazone), was removed from the market due to liver toxicity. Earlier this year, the Cochrane Library published a meta-analysis of Actos (pioglitazone), a thiazolidinedione similar to Avandia, which implicated it in edema and heart failure. In the meantime, patients using any of the insulin sensitizers should talk to their health care provider to determine the most appropriate course of action. Patients should not stop taking any prescribed medications without first discussing the issue with their health care provider. Now is the time to talk to your patients about the risks associated with diabetes. Using any drug increases your risk for complications. But, as the studies have shown, increasing your physical activity can provide the same benefits and even greater benefits in reducing your risk factors for the complications of diabetes and other diseases. Just like we all know that physical activity is an effective treatment for diabetes, yet we would rather just write another prescription for a drug treatment, rather then write a prescription for physical activity, which we all know works and is effective.
Lets first look at the costs of treating diabetes with Avandia. The cost to treat diabetes with Avandia can be $120 dollars a month, or 1500 a year or 15,000 for 10 years and increases your risk for DEATH!. A pedometer costs $20 dollars over 10 years, and when used effectively will reduce the risk for heart failure and DEATH! We can take the increased risk of death from cardiovascular of 64% and turn it around and decrease your risk for cardiovascular death by 64%, that is a change of 128%. As in the DPT trials, and even the Dream study, which used Avandia to reduce the risk of diabetes physical activity was shown to be as effective, if not more then the oral treatments used in the studies.
Lets look at a couple of the studies that, shows this controversy has but only one conclusion. In a Finish study with postmenopausal women over 10 years it was found that walking 1 mile or more a day reduced the risk for heart disease by 82%. In a study in Washington State they found that walking at least 1 hour per week, which is less then 9 minutes a day can reduce the risk for sudden cardiac death by 73%. In a study of 40,000 American females they found that walking at least 1 hour a week, (less then 10 minutes a day) reduced the risk for coronary artery disease by 51%. In a study of over 73,000 American women aged 50-79, walking for 2.5 hours a week reduced the risk for all cardiovascular events by 30%. In a study of 1500 men, walking at least 2.5 hours a week (14 minutes a day) lowered the risk of heat attack by 69%. So, why replace one drug with another that has other risk factors, when we can simply provide a 20 dollar pedometer and tell our patients to increase their physical activity? Now is a great time to have the discussion with your patients and let them know that there are other alternatives to taking drugs that are more effective with no risk factors. But, just telling them may not be good enough, make them responsible for reporting to you their physical activity by using a pedometer and setting goals for the number of steps they take each and every day. If they can report to you their blood sugars, then report their steps! Now imagine what would happen if we also had them responsible for the number of carbohydrates that they consume each day and maybe reduce them by just 100 grams, what could happen? And if all else fails, consider using the most safe and effective drug: INSULIN I
If you would like to share your comments, contact me at publisher@diabetesincontrol.com Steve Freed, Publisher Diabetes in Control.com Pharmacist and Diabetes Educator
Steve Freed, Pharmacist, Diabetes Educator, pedometrist and publisher of http://www.diabetesincontrol.com the leading on-line newsletter for diabetes information for medical professionals and patients with diabetes.
Article Source: http://EzineArticles.com/?expert=Steve_Freed http://EzineArticles.com/?Insulin-Sensitizers-Good-or-Bad&id=929953
Insulin Sensitizers Good or Bad
To use an insulin sensitizer or not! What is better and safer? With the current New England Journal Article on Avandia and it's increased risks for cardiovascular problems, I believe we have missed the whole point of the article.
To use an insulin sensitizer or not! What is better and safer? With the current New England Journal Article on Avandia and it's increased risks for cardiovascular problems, I believe we have missed the whole point of the article.
Juvenile Diabetes - Early Signs And Symptoms In Children By Jitesh Arora: What are the early signs and symptoms of juvenile diabetes? Juvenile diabetes is having a sudden onset. The cause of juvenile diabetes is destruction of insulin producing beta cells of the pancreas. Insulin is a hormone produced by the pancreas which changes the glucose in the energy needed by the body. The most common in children is type 1 diabetes mellitus. The early signs and symptoms of the disease include:
Diabetes Insipidus: Unlike other types of diabetes such as Diabetes Mellitus Diabetes Insipidus is a disease that is linked to the pituitary gland in the brain. When the word diabetes is mentioned most people will assume that we are speaking of Diabetes Mellitus (Sugar Diabetes). Diabetes Insipidus though is not caused by a lack of insulin or the lack of insulin regulation. Diabetes Insipidus happens when the pituitary gland does not make enough of the hormone ADH.
Holidays And Diabetes: Six Tips For Enjoying Season's Treats - By Cydne Kaelin - The hyper-abundance of rich foods, beverages and desserts can wreak havoc on the diets of most during the holidays. If you have diabetes or pre-diabetes, holiday dining can pose considerable challenges.
Diabetes Guide: A Very Quick And Brief Sneak Peek On Diabetes By Ashish Jain
Of all the afflictions of modern living, diabetes is one that is most common in this century. This unique disease is an affliction that sometimes goes undetected in people for a long while before one actually spots it. It is also a disease that does not confine one to bed rest like a bout of flu, or a viral infection. It shows no outward symptoms like pain or swelling or cough or discomfort. The only suspicion aside this illness is an unnatural craving for sweet things, which again, often gets dismissed as a weakness for sweets or as possessing a sweet tooth
Of all the afflictions of modern living, diabetes is one that is most common in this century. This unique disease is an affliction that sometimes goes undetected in people for a long while before one actually spots it. It is also a disease that does not confine one to bed rest like a bout of flu, or a viral infection. It shows no outward symptoms like pain or swelling or cough or discomfort. The only suspicion aside this illness is an unnatural craving for sweet things, which again, often gets dismissed as a weakness for sweets or as possessing a sweet tooth
10 Best Home Remedies for Diabetes
Diabetes is a disorder of metabolism the way our bodies use digested food for development and energy. It is widely accepted as one of the leading causes of death and disability in the United States. It is connected with long-term complications that affect
Diabetes is a disorder of metabolism the way our bodies use digested food for development and energy. It is widely accepted as one of the leading causes of death and disability in the United States. It is connected with long-term complications that affect
These are the approaches for a cure that are currently being pursued:
-
- Transplantation of the Pancreas.
- -
Transplantation of
Islet cells which produce insulin.
- -
Development of an
artificial Pancreas.
- -
Genetic Manipulation,
which will create pseudo islet cells by inserting the human insulin
gene into
fat or muscle cells which do not normally make their own insulin.
Resources: